Allosteric activation of a bacterial stress sensor

Publication Year
2007

Type

Journal Article
Abstract

In Gram-negative bacteria, envelope stress signals such as unfolded outer membrane proteins (OMP) activate the periplasmic protease DegS. This protease then triggers a cellular pathway to alleviate the stress. Now Sohn et al. (2007) show conclusively that inhibition of DegS is relieved allosterically by binding of the C-terminal sequences in unfolded OMPs to the PDZ domain of DegS.

Journal
Cell
Volume
131
Issue
3
Pages
441-3
Date Published
11/2007
ISSN Number
0092-8674
Alternate Journal
Cell
PMID
17981109