@article{168421,
  keywords = {Escherichia coli, Substrate Specificity, Transcription Factors, Membrane Proteins, Mutant Proteins, Protein Binding, Escherichia coli Proteins, Enzyme Activation, Peptides, Bacterial Outer Membrane Proteins, Allosteric Regulation, PDZ Domains},
  author = {Nieng Yan and Yigong Shi},
  title = {Allosteric activation of a bacterial stress sensor},
  abstract = {<p>In Gram-negative bacteria, envelope stress signals such as unfolded outer membrane proteins (OMP) activate the periplasmic protease DegS. This protease then triggers a cellular pathway to alleviate the stress. Now Sohn et al. (2007) show conclusively that inhibition of DegS is relieved allosterically by binding of the C-terminal sequences in unfolded OMPs to the PDZ domain of DegS.</p>
},
  year = {2007},
  journal = {Cell},
  volume = {131},
  pages = {441-3},
  month = {11/2007},
  issn = {0092-8674},
  doi = {10.1016/j.cell.2007.10.021},
  language = {eng},
}